Vardenafil (Levitra, Staxyn): Uses, Side Effects, Interactions, Pictures, Warnings & Dosing - WebMD
What is vardenafil used for?
Vardenafil is commonly used for erectile dysfunction, a medical condition characterized by the inability to achieve or maintain an erection sufficient for sexual intercourse. This condition can lead to significant distress and may affect self-esteem, relationships, and overall quality of life.
In addition to treating erectile dysfunction, vardenafil may be utilized for other medical indications as determined by your qualified healthcare provider, based on individual patient needs and professional judgment.
How does vardenafil work (mechanism of action)?
Vardenafil operates by inhibiting an enzyme known as PDE5 (phosphodiesterase type 5), which plays a crucial role in regulating blood flow. By blocking this enzyme, vardenafil facilitates the relaxation of smooth muscles and dilation of blood vessels in the penis, thus increasing blood flow during sexual arousal and making it easier to achieve and maintain an erection.
How is vardenafil supplied (dosage forms)?
Brands and other names
- Staxyn
- Levitra
Dosage forms and strengths
- Available as 2.5 mg, 5 mg, 10 mg, and 20 mg oral tablets
- 10 mg orally disintegrating tablets that dissolve on the tongue
How should I store vardenafil?
Vardenafil should be stored at room temperature, ideally between 68°F to 77°F (20°C to 25°C). Short-term exposure to temperatures ranging from 59°F to 86°F (15°C to 30°C) may be acceptable, such as during transport. Always keep it in a cool, dry location away from excessive moisture.
Make sure to keep orally disintegrating tablets in their original blister pack until just before use. Do not consume if the blister pack appears damaged or compromised in any way.
Side Effects
What are the most common side effects of vardenafil?
The most commonly reported side effects of vardenafil include but are not limited to the following. These side effects may differ in prevalence and severity depending on the specific formulation of vardenafil that is prescribed. If you experience any of these side effects and they become bothersome, it's important to communicate this with your healthcare provider.
- Headache
- Flushing of the skin
- Stuffy or runny nose, or inflammation of the sinuses
- Upset stomach and gastrointestinal discomfort
- Flu-like symptoms, which may include fatigue and malaise
- Dizziness, which may lead to difficulties in balance
- Nausea
- Back pain, which may affect mobility and comfort
It is essential to note that there could be additional side effects related to vardenafil that are not documented here. If you suspect that you are encountering a side effect from this medication, you should reach out to your healthcare provider without delay. In the United States, side effects can be reported to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. For Canadian residents, side effects can be reported to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of vardenafil?
Although less frequent, the serious side effects associated with vardenafil are outlined below, along with actions to take if they occur.
Severe Allergic Reactions. Vardenafil may trigger allergic reactions, which can be life-threatening. If you experience any symptoms indicative of a severe allergic reaction, you must discontinue the use of vardenafil and seek immediate medical assistance.
- Difficulty breathing or wheezing
- Palpitations or racing heart rate
- Fever or general unwellness
- Swelling of lymph nodes
- Facial swelling, including lips, mouth, tongue, or throat
- Difficulty swallowing or sensation of throat tightness
- Itching, skin rash, or development of hives
- Feelings of nausea or episodes of vomiting
- Dizziness, lightheadedness, or fainting spells
- Severe abdominal cramps
- Pain in the joints
Painful, Prolonged Erection (Priapism). This condition may result from vardenafil and is characterized by an erection that is not only prolonged but also painful, and may arise without sexual stimulation. If not addressed promptly, priapism could lead to permanent damage to the penis. Seek emergency medical help if you experience the following symptoms related to priapism.
- Erection lasting longer than four hours
- Erection that occurs without sexual excitement
- Painful or tender sensation in the penis
Vision Changes. Occasionally, vardenafil can cause temporary but mild alterations in vision, such as a bluish tint, unusual color perceptions, blurred eyesight, or sensitivity to light. Though rare, some users have reported experiencing permanent vision loss. If you notice sudden vision changes, especially loss in one or both eyes, discontinue vardenafil and seek immediate medical assistance.
Hearing Loss. There are reports of sudden hearing loss associated with vardenafil use, frequently occurring alongside symptoms such as dizziness or tinnitus (ringing in the ears). If you experience sudden hearing impairment, promptly discontinue the medication and consult your healthcare provider.
Heart Rhythm Changes. Vardenafil may lead to a rare but serious heart rhythm disorder known as QT prolongation. Individuals with long QT syndrome or those taking specific heart rhythm medications may be at elevated risk. It is crucial to inform your healthcare provider immediately if you experience fainting or significant changes in heart rate or rhythm, including a rapid or irregular heartbeat.
Low Blood Pressure (Hypotension). This medication may result in a transient and mild drop in blood pressure. Those with pre-existing health conditions or who are on antihypertensive medications may have an increased risk. If you experience dizziness or a feeling of lightheadedness, it is advised to lie down and report any symptoms of low blood pressure to your healthcare provider immediately.
- Dizziness or a sensation of lightheadedness
- Feelings of weakness or fatigue
- Fainting episodes
- Confusion or disorientation
Warnings & Precautions
Who should not take vardenafil?
Allergies to Ingredients. Individuals with known allergies to any ingredients found in vardenafil should refrain from using this medication.
- Vardenafil
- Levitra
- Staxyn
- Other components found in the specific medication prescribed
Pharmacists are equipped to provide detailed information regarding the ingredients present in various vardenafil formulations available.
Drug Interactions. Caution is advised as vardenafil should not be used concurrently with certain medications. Always inform your healthcare provider of any prescription or over-the-counter medications, dietary supplements, herbal products, and vitamins you are currently taking, as this can influence treatment decisions.
What should I know about vardenafil before taking it?
Vardenafil should only be taken when prescribed by a qualified healthcare provider. It is vital to follow their instructions carefully.
Do not share this medication with anyone else, even if they present with similar symptoms, as inappropriate usage may pose serious health risks.
Keep vardenafil securely out of reach of children to prevent accidental ingestion.
Do not chew, cut, or crush orally disintegrating tablets; they should be allowed to dissolve fully on the tongue.
Engaging in sexual activity can place additional strain on the cardiovascular system, particularly in individuals with certain pre-existing heart conditions, such as a recent myocardial infarction. Consult your healthcare provider to assess whether your heart is sufficiently healthy for sexual activity. If you encounter chest pain, dizziness, or nausea during sexual intercourse, cease the activity and seek immediate medical advice.
Vardenafil does not confer protection against sexually transmitted infections, including HIV, and thus safe sexual practices should always be observed.
This medication is categorized under phosphodiesterase type 5 (PDE-5) inhibitors, which are prescribed for erectile dysfunction or pulmonary arterial hypertension. It is essential to avoid simultaneous administration with other PDE-5 inhibitors, which include but are not limited to avanafil (Stendra), sildenafil (Viagra, Revatio, and others), and tadalafil (Cialis and others).
What should I tell my healthcare provider before taking vardenafil?
Inform your healthcare provider about your complete health history and any prescription or over-the-counter medications, vitamins, minerals, herbal products, and supplements you are currently utilizing. This information is crucial in determining whether vardenafil is an appropriate option for you.
Please ensure that you share any of the following:
Phenylketonuria (PKU). Vardenafil oral tablets contain phenylalanine, which can pose significant health risks for individuals with PKU. Advise your healthcare provider if you have this condition so they can recommend suitable alternate treatments.
Other Current and Past Health Conditions. Make sure to inform your healthcare provider if you have any of the following health concerns:
- Cardiovascular issues, such as arrhythmias, angina, or congestive heart failure
- Recent heart attack, stroke, or surgical intervention related to heart conditions within the last six months
- Diagnosis of low blood pressure
- Diagnosis of hypertension that remains uncontrolled despite medication
- Peyronie's disease, characterized by an abnormal curvature of the penis
- Experiencing prolonged erections lasting beyond four hours
- Blood disorders, including sickle cell disease
- A hereditary eye disorder known as retinitis pigmentosa
- Previous vision loss or issues impacting the optic nerve
- Other health issues that could increase the risk of optic nerve damage, such as diabetes, high cholesterol levels, tobacco use, age over 50, or anatomical abnormalities of the optic disc
- Existing hearing challenges or auditory issues
- History of bleeding disorders
- History of stomach ulcers
- Liver dysfunction or disease
- Undergoing renal dialysis
- Pulmonary veno-occlusive disease, which entails blockage of blood vessels in the lungs
Pregnancy. Individuals who can become pregnant are typically not prescribed vardenafil. The effects of vardenafil on pregnancy and fetal health remain largely unknown. Communicate with your healthcare provider promptly if you are pregnant or considering becoming pregnant.
Breastfeeding. Vardenafil is not generally prescribed to individuals who breastfeed. The potential for this medication to transfer into breast milk is unclear, so discuss your breastfeeding status with your healthcare provider if applicable.
Interactions
Does vardenafil interact with foods or drinks?
It is advisable to avoid grapefruit and products containing grapefruit while taking vardenafil. Grapefruit and grapefruit juice can significantly raise the levels of vardenafil in your bloodstream, leading to an increased likelihood of experiencing adverse side effects.
Vardenafil orally disintegrating tablets should not be ingested with water or other liquids; they are designed to dissolve on the tongue, where they should remain intact until fully dissolved.
At present, there are no documented interactions between vardenafil and alcoholic beverages, though moderation is advised.
Does vardenafil interact with other medicines (drug interactions)?
Always disclose to your healthcare provider any medications—both prescription and over-the-counter (OTC)—that you are currently taking, including vitamins, minerals, herbal supplements, and any other products you may have used.
Specifically, ensure you mention if you are using any of the following medications prior to initiating vardenafil:
- Nitrates, including nitroglycerin (Nitro-Dur, Nitrostat, and others) or isosorbide, which are commonly prescribed for angina or ischemic heart disease, as well as recreational drugs such as amyl nitrite (“poppers”)
- Guanylate cyclase stimulators, such as riociguat (Adempas) or vericiguat (Verquvo), indicated for certain cardiovascular and pulmonary conditions
- Alpha-blockers, like alfuzosin (Uroxatral), doxazosin (Cardura), dutasteride, prazosin (Minipress), silodosin (Rapaflo), tamsulosin (Flomax), or terazosin (Hytrin), which may be used to treat hypertension or benign prostatic hyperplasia
- Any antihypertensive medications
- Protease inhibitors, such as ritonavir (Norvir) or atazanavir (Reyataz), which are frequently involved in HIV treatment
- Fungal infection treatments, including ketoconazole or itraconazole (Sporanox, Tolsura)
- Macrolide antibiotics such as erythromycin (Ery-Tab and others) or clarithromycin (Biaxin), used for bacterial infections
- Cobicistat (Tybost), commonly administered in HIV therapy
- Antiarrhythmic drugs, including amiodarone (Pacerone and others), procainamide, quinidine, or sotalol (Betapace)
- Any other medications indicated for the management of erectile dysfunction
A variety of other medications may modify vardenafil's blood concentration levels, and vice versa. It is crucial to keep your healthcare provider informed about all medications you have been prescribed or have used recently.
This list may not encompass all medications that can interact with vardenafil. It's always best to consult your healthcare provider for a comprehensive review.
Does interact with other drugs you are taking?
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Overdose/Missed Dose
What should I do if I accidentally take too much vardenafil?
If you or someone else has ingested an overdose of vardenafil, it is imperative to seek medical attention immediately by calling 911 or reaching out to a Poison Control center at 800-222-1222. Taking more than the prescribed amount can lead to serious side effects and complications.
What should I do if I miss a dose of vardenafil?
Vardenafil is typically taken on an as-needed basis for sexual activity. Adhere to the guidance provided by your healthcare provider, which is usually to take it approximately one hour before engaging in sexual activity. Do not take double doses or exceed the prescribed quantity.